LP21132-3
Chikungunya virus
Active
Descriptions
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. PMID: 20111039
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage.
Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Chikungunya virus
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-10-16
- Construct for LOINC Short Name
- CHIKV
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 基孔肯亚病毒 Synonyms: 奇昆古尼亚病毒; |
| fr-CA | French (Canada) | Virus Chikungunya |
| es-ES | Spanish (Spain) | Virus Chikungunya |
| it-IT | Italian (Italy) | Chikungunya virus Synonyms: CHIK |
| tr-TR | Turkish (Turkey) | Chikungunya virus |
| ru-RU | Russian (Russian Federation) | Чикунгунья вирус |
| nl-NL | Dutch (Netherlands) | Chikungunya-virus |
| fr-BE | French (Belgium) | Virus Chikungunya |
| pl-PL | Polish (Poland) | Wirus Chikungunya Synonyms: Wirus Chikungunya |
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