Version 2.78

Description

Microsatellite instability (MSI) is a change in the number of repeats of a specific DNA marker in cancer cells compared to the number of repeats present in non-cancerous cells of the same patient. Different tumor types are associated with different MSI markers, and both the presence of MSI in specific markers as well as the the number of distinct markers demonstrating MSI is important. Tumor cells are classified as being stable, having high instability (MSI-H), or having low instability (MSI-L) based on the number of markers demonstrating MSI. MSI analysis may help guide therapy and be a prognostic indicator. Specific MSI markers include BAT25, BAT26, D2S123, D5S346, D17S2720, NR21, NR24 and MONO27. MSI has been most studied in colorectal cancer, and colorectal tumors that are MSI-H are more likely to be carcinomas than adenomas. MSI has also been studied in other types of cancer, including gastric cancer, breast cancer, lung cancer and Wilms tumor. Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Microsatellite markers exhibiting instability
Part Type
Component (Describes the core component or analyte measured)
Created On
2016-04-29
Construct for LOINC Short Name
MSI mark found

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP212220-0

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 表现不稳定性的微卫星标记
Synonyms: 表现（展现、体现、显现、显示、存在）不稳定性的微卫星标记
es-ES Spanish (Spain) Marcadores de inestabilidad de microsatelites
it-IT Italian (Italy) Marcatori di microsatelliti che dimostrano instabilità