LP21368-3
Sirolimus
Active
Descriptions
A macrolide compound obtained from Streptomyces hygroscopicus. It selectively blocks the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. It is marketed under the drug name Rapamune (Streptomyces hygroscopicus was first isloated in a soil sample from an Easter Island called "Rapa Nui" thus the name Rapamune). Source: National Library of Medicine, MeSH 2006
Sirolimus, also known as rapamycin, is a macrolide compound that inhibits lymphocyte proliferation and is used as an immunosuppressant to prevent rejection in organ transplantation. It inhibits T-cell activation and proliferation by inhibiting the response to interleukin 2 (IL-2). Its mode of action differs from that of other immunosuppressants (SN Sehga, Clin Biochem, 31:335, 1998) most notably by not being a calcineurin inhibitor. Its inhibitory action is mediated via a cytosolic protein, FK-binding protein 12. Sirolimus is variably absorbed; levels need to monitored to achieve the therapeutic target while avoiding toxic levels. Sirolimus is marketed under the trade name Rapamune. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Sirolimus
- Part Display Name
- Sirolimus
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2001-01-30
- Construct for LOINC Short Name
- Sirolimus
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 西罗莫司 Synonyms: 瑞帕霉素; |
| es-ES | Spanish (Spain) | Sirolimus |
| it-IT | Italian (Italy) | Sirolimus |
| et-EE | Estonian (Estonia) | Siroliimus |
| tr-TR | Turkish (Turkey) | Sirolimus |
| ru-RU | Russian (Russian Federation) | Сиролимус Synonyms: Рапамицин |
| fr-BE | French (Belgium) | Sirolimus |
| fr-CA | French (Canada) | Sirolimus |
| nl-NL | Dutch (Netherlands) | sirolimus |
| el-GR | Greek (Greece) | Σιρόλιμους Synonyms: Σιρόλιμους |
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