LP220336-4
Nuclear Ab.IgG pattern.coarse speckled
Active
Description
There are many nuclear staining patterns seen on HEp-2 cells: homogeneous, speckled, nucleolar, nuclear membranous, centromeric, nuclear dot and pleomorphic. The homogeneous pattern is seen when the condensed chromosomes and interphase chromatin stain and is associated with anti-dsDNA antibodies, antibodies to nucleosomal components, and anti-histone antibodies. Most antibodies are IgG, but IgM and IgA have also been detected. PMID: 19897433 There are two speckled patterns: fine and coarse. The fine speckled pattern has fine nuclear staining with unstained metaphase chromatin, which is associated with anti-Ro and anti-La antibodies. The coarse staining pattern has coarse granular nuclear staining, caused by anti-U1-RNP and anti-Sm antibodies. The nucleolar staining pattern is associated with many antibodies including anti-Scl-70, anti-PM-Scl, anti-fibrillarin and anti-Th/To. Nuclear membrane staining appears as a fluorescent ring around the cell nucleus and are produced by anti-gp210 and anti-p62 antibodies. The centromere pattern shows multiple nuclear dots in interphase and mitotic cells, corresponding to the number of chromosomes in the cell. Nuclear dot patterns show between 13-25 nuclear dots in interphase cells and are produced by anti-sp100 antibodies. Pleomorphic pattern is caused by antibodies to the proliferating cell nuclear antigen. PMID: 7604300 PMID: 11863229 PMID: 11303304 PMID: 19499499 Indirect immunofluorescence has been shown to be slightly superior compared to ELISA in detection of ANA from HEp-2 cells. PMID: 11430499 Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia
Basic Part Properties
- Part Name
- Nuclear Ab.IgG pattern.coarse speckled
- Part Display Name
- Coarse speckled nuclear IgG pattern
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-06-29
- Construct for LOINC Short Name
- ANA IgG coarse speck
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 细胞核抗体.IgG 模式.粗斑点型 Synonyms: 细胞核抗体（ANA、 |
| es-ES | Spanish (Spain) | Anticuerpo nuclear IgG patrón moteado grueso |
| it-IT | Italian (Italy) | Ab nucleari.profilo IgG.punteggiati grossolanamente Synonyms: Profilo IgG nucleari punteggiati grossolanamente |
| nl-NL | Dutch (Netherlands) | nucleaire As.IgG patroon.grof gespikkeld |
| fr-FR | French (France) | Noyau anticorps IgG aspect nucléaire moucheté à gros grains |
| pl-PL | Polish (Poland) | Jądrowe Ab.IgG wzór.gruboziarnisty Synonyms: Wzór gruboziarnisty przeciwciał przeciwjądrowych IgG |
| el-GR | Greek (Greece) | Μοτίβο πυρηνικών αντισωμάτων IgG.αδρά λεπτόκοκκα Synonyms: Μοτίβο πυρηνικών αντισωμάτων IgG.αδρά λεπτόκοκκα |
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