LP220403-2
MDA5
Active
Description
MDA5, more formally known as interferon-induced helicase C domain-containing protein 1, is an immune receptor for viral nucleic acids and plays a major role in activating antiviral responses, including the induction of type I interferons and proinflammatory cytokines. Anti-MDA5 autoantibodies, also known as anti-CADM-140, are associated with autoimmune disorders including dermatomyositis and interstitial lung disease. [UniProt: Q9BYX4] Anti-MDA5 autoantibodies are also found in a subset of patients with juvenile dermatomyositis (JDM) who have polyarthritis and ulcerative skin disease but milder muscle disease. Anti-MDA5 assays may be useful during the work-up of patients with inflammatory disorders and may help guide treatment. PMID: 24989778 Source: Regenstrief LOINC, PMID: 24989778
Basic Part Properties
- Part Display Name
- MDA5
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-07-07
- Construct for LOINC Short Name
- MDA5
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP220403-2
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | MDA5 Synonyms: 干扰素诱导型解旋酶 C 结构域包含型蛋白 1; |
| es-ES | Spanish (Spain) | MDA5 |
| it-IT | Italian (Italy) | MDA5 |
| nl-NL | Dutch (Netherlands) | MDA5 |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright