LP248278-6
Bacterial beta-lactam resistance ESBL blaCTX-M-1 Group gene
Active
Description
Extended-spectrum beta-lactamases (ESBL) are enzymes produced by some bacteria that are resistant to the majority of beta-lactam antibiotics which include the penicillins, cephalosporins and the monobactam aztreonam. [https://www.uptodate.com/contents/extended-spectrum-beta-lactamases] Organisms producing CTX-M type ESBL enzymes have been isolated worldwide with more than 150 enzymes identified. These enzymes have been classified into seven major phylogenetic groups: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25, CTX-M-74 and CTX-M-75. The rare ESBL type CTX-M-8 has been isolated in Germany, mainly in E. coli, but also in Salmonella and E. aerogenes. CTX-M type ESBL have been isolated worldwide and their incidence has increased dramatically and is still increasing leading to a major therapeutic issue. Currently more than 150 allelic variants of CTX-M have been identified. These enzymes are classified in five major phylogenetic groups based on their gene sequences: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25; two additional groups have been reported recently: CTX-M-74 and CTX-M-75. The dissemination of these enzymes has caused an increased use of carbapenems for treatment of infections which carries its own risk of furthering resistance. PMID: 25234380 The genes are named with the prefix "bla", which stands for "beta-lactam", followed by the enzyme, for example, blaCTX-M-1. Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Bacterial beta-lactam resistance ESBL blaCTX-M-1 Group gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2017-02-20
- Construct for LOINC Short Name
- ESBL blaCTX-M-1 Grp gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Grupo genes bacterianos ESBL blaCTX-M-1 resistentes a beta-lactámicos |
| zh-CN | Chinese (China) | 细菌 beta-内酰胺耐药 ESBL blaCTX-M-1 组基因 Synonyms: 细菌 beta-内酰胺（β-内酰胺）耐药（抗性、 |
| it-IT | Italian (Italy) | Resistenza batterica beta-lactamica, gene Gruppo ESBL blaCTX-M-1 Synonyms: Gene Gruppo ESBL blaCTX-M-1 di resistenza batterica beta-lactamica |
| nl-NL | Dutch (Netherlands) | bacteriële bètalactamresistentie ESBL blaCTX-M-1 groep gen |
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