Version 2.77

Description

Extended-spectrum beta-lactamases (ESBL) are enzymes produced by some bacteria that are resistant to the majority of beta-lactam antibiotics which include the penicillins, cephalosporins and the monobactam aztreonam. [https://www.uptodate.com/contents/extended-spectrum-beta-lactamases] Organisms producing CTX-M type ESBL enzymes have been isolated worldwide with more than 150 enzymes identified. These enzymes have been classified into seven major phylogenetic groups: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25, CTX-M-74 and CTX-M-75. The rare ESBL type CTX-M-8 has been isolated in Germany, mainly in E. coli, but also in Salmonella and E. aerogenes. CTX-M type ESBL have been isolated worldwide and their incidence has increased dramatically and is still increasing leading to a major therapeutic issue. Currently more than 150 allelic variants of CTX-M have been identified. These enzymes are classified in five major phylogenetic groups based on their gene sequences: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25; two additional groups have been reported recently: CTX-M-74 and CTX-M-75. The dissemination of these enzymes has caused an increased use of carbapenems for treatment of infections which carries its own risk of furthering resistance. PMID: 25234380 The genes are named with the prefix "bla", which stands for "beta-lactam", followed by the enzyme, for example, blaCTX-M-1. Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-02-20
Construct for LOINC Short Name
blaCTX-M-8+blaCTX-M-25 Grp

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP248281-0

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Grupo genes bacterianos ESBL blaCTX-M-8+blaCTX-M-25 resistente a beta-lactámicos
zh-CN Chinese (China) 细菌 beta-内酰胺耐药 ESBL blaCTX-M-8+blaCTX-M-25 组基因
Synonyms: 细菌 beta-内酰胺(β-内酰胺)耐药(抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型) ESBL(超广谱β-内酰胺酶) blaCTX-M-8+blaCTX-M-25 组基因
it-IT Italian (Italy) Resistenza batterica beta-lactamica, geni Gruppo ESBL blaCTX-M-8+blaCTX-M-25
Synonyms: Geni Gruppo ESBL blaCTX-M-8+blaCTX-M-25 di resiste
nl-NL Dutch (Netherlands) bacteriële bètalactamresistentie ESBL blaCTX-M-8 + blaCTX-M-25 groep genen