LP249101-9
Bacterial colistin resistance mcr-1 gene
Active
Description
The mobilized colistin resistance genes (mcr-1 to mcr-5, and variants) are located on a plasmid within bacterial cells and affect the ability of antibiotics, including polymyxins and colistin, to bind to the bacteria. The mode of action of the antibiotics is to bind to the outer membrane of the phosphate group of lipid A lipopolysaccharide and to intercalate into the inner membrane forming pores that result in bacterial lysis. The polymyxins & colistin are the last line of defense used to treat multidrug resistant gram-negative bacteria so the emergence of the mcr genes in Enterobacteriaceae, including Klebsiella pneumoniae, is onerous and challenging to public health. PMID: 27893854 PMID: 29439754 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Bacterial colistin resistance mcr-1 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2017-04-06
- Construct for LOINC Short Name
- Colistin res mcr-1
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP249101-9
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | gen bacteriano mcr-1 resistente a colistina |
| zh-CN | Chinese (China) | 细菌粘菌素耐药 mcr-1 基因 Synonyms: 细菌粘菌素（多粘菌素 E、 |
| it-IT | Italian (Italy) | Gene mrc-1 di resistenza batterica alla colistina |
| nl-NL | Dutch (Netherlands) | bacteriële colistineresistentie mcr-1-gen Synonyms: bacterieel colistine resistentie mcr-1 gen |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright