Version 2.77

Description

The Stx1 toxin A subunit is encoded by the stx1 gene [www.uniprot.org/uniprot/ ?query=stx1+escherichia+coli&sort=score] and the Stx2 toxin A subunit is encoded by the stx2 gene.[UniProt: K0JD26] Stx1a and Stx2a are produced by some serogroups of Escherichia coli (also known as Vero toxins and previously referred to as Shiga-like toxins) are two cytotoxins that cause hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). The two toxins produce similar symptoms, but are immunologically unique. Both toxins are composed of a single copy of subunit A and five copies of subunit B. Stx1a and Stx1b induce host cell apoptosis by removing an adenine residue from the 28S rRNA of the 60S ribosome, with RNA-N-glycosidase activity provided by subunit A. The five B subunits bind to the host cell receptor present on endothelial cells. PMID: 25530917 Shigella toxin-producing Escherichia coli (STEC) has become a serious food-borne pathogen. Outbreaks of STEC have been associated with the consumption of pork products resulting in HC and HUS. STEC in swine has been demonstrated to cause edema disease. Epidemiological studies throughout the world have proven that STEC can be harbored and shed by domestic swine. PMID: 24397985 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Escherichia coli Stx1 toxin stx1 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-07-17
Construct for LOINC Short Name
EC stx1 gene

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP262487-4

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen stx1 Escherichia coli
it-IT Italian (Italy) Escherichia coli tossina Stx1, gene stx1
zh-CN Chinese (China) 大肠埃希菌 Stx1 毒素 stx1 基因
Synonyms: 大肠埃希菌（E coli、大肠埃希氏杆菌、大肠埃希氏菌、大肠杆菌） Stx1 毒素 stx1 基因;大肠埃希菌 stx1 基因
nl-NL Dutch (Netherlands) Escherichia coli Stx1-toxine stx1-gen