Version 2.80

Description

Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt: Q70Q79]; [UniProt: Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea. PMID: 8528070 The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea. PMID: 23716609 Source: Regenstrief LOINC

Basic Part Properties

Part Name
Escherichia coli enterotoxigenic stb gene
Part Display Name
Escherichia coli enterotoxigenic stb gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-07-18
Construct for LOINC Short Name
ETEC stb gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP262492-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 大肠埃希菌肠产毒素型 stb 基因
Synonyms: 大肠埃希菌(E coli、大肠埃希氏杆菌、大肠埃希氏菌、大肠杆菌)肠产毒素型(肠产毒素性、产肠毒素性、产肠毒素型、肠毒性、肠毒型、产肠毒性、产肠毒型) stb 基因
es-ES Spanish (Spain) Gen stb Escherichia coli enterotoxigenico
it-IT Italian (Italy) Escherichia coli enterotossigeni gene stb
nl-NL Dutch (Netherlands) Escherichia coli enterotoxine-gen sta-gen
el-GR Greek (Greece) Γονίδιο stb του εντεροτοξικού Escherichia coli (Κολοβακτηρίδιο)
Synonyms: Γονίδιο stb του εντεροτοξικού Escherichia coli (Κολοβακτηρίδιο)