Version 2.78

Description

Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt: Q70Q79]; [UniProt: Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea. PMID: 8528070 The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea. PMID: 23716609 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Escherichia coli enterotoxigenic sta gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-07-18
Construct for LOINC Short Name
ETEC sta gene

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP262495-7

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen sta Escherichia coli enterotoxigenico
it-IT Italian (Italy) Escherichia coli enterotossigeni gene sta
zh-CN Chinese (China) 大肠埃希菌肠产毒素型 sta 基因
Synonyms: 大肠埃希菌（E coli、大肠埃希氏杆菌、大肠埃希氏菌、大肠杆菌）肠产毒素型（肠产毒素性、产肠毒素性、产肠毒素型、肠毒性、肠毒型、产肠毒性、产肠毒型） sta 基因
nl-NL Dutch (Netherlands) Escherichia coli enterotoxine-gen hittegevoelig toxine