LP263474-1
Rotavirus A VP4 gene
Active
Description
Rotaviruses are non-enveloped, multilayered, icosahedral viruses composed of an outer layer, an inner layer, and a core. After the immature, double-layered virus is assembled in the host cell cytoplasm, they bud across the endoplasmic reticulum (ER) and acquire a temporary membrane that has on its surface the ER resident viral glycoproteins NSP4, VP4 and VP7. The virus loses its temporary membrane and the NSP4 glycoprotein as it moves toward the center of the ER cisternae. The VP4 and VP7 proteins are pushed to the outermost membrane layer and become the mature triple-layered rotavirus. The outer capsid glycoprotein VP7 is believed to be important for the attachment to and entry in the host cell. After it enters the host cell, the VP7 glycoprotein is lost. [UniProt: Q89865]When the host cell lyses, the mature virus are released. There are groups of rotavirus, A through H. Groups A, B, C, and H are associated with an acute gastroenteritis and are found in humans and animals. Groups D, E, F, and G are found only in animals. Rotavirus A (RVA) cause an acute gastroenteritis in children and animals. RVA is the most common infectious organism to cause severe gastroenteritis in children less than 3 years of age. It is estimated that 95% of children between the ages of 3 and 5 will become infected with RVA. Approximately 8000 children under 5 years of age in Latin America and the Caribbean die of acute enteritis caused by RVA. PMID: 2556635http://www.sciencedirect.com/science/article/pii/S004268220700400X?via%3Dihub PMID: 27462899The four serotypes of rotavirus that infect swine include A, B, C and E.https://vetmed.iastate.edu/vdpam/FSVD/swine/index-diseases/rotaviral-enteritis Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Rotavirus A VP4 gene
- Part Display Name
- Rotavirus A VP4 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2017-09-15
- Construct for LOINC Short Name
- RVA VP4
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gen VP4 rotavirus A |
| it-IT | Italian (Italy) | Rotavirus A, gene VP4 |
| zh-CN | Chinese (China) | 轮状病毒 A VP4 基因 Synonyms: 轮状病毒（ROTAV、 |
| fr-FR | French (France) | Rotavirus A gène VP4 |
| nl-NL | Dutch (Netherlands) | Rotavirus A VP4-gen |
| pl-PL | Polish (Poland) | Rotawirus A gen VP4 Synonyms: GenVP4 Rootawirusa A |
| el-GR | Greek (Greece) | Γονίδιο ροταϊού A VP4 Synonyms: Γονίδιο ροταϊού A VP4 |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://