LP263674-6
Cells.CD4-CD8-CD45R+TCR alpha beta+
Active
Description
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder that occurs when a mutation in the FAS gene prevents the normal death cycle of the lymphocytic white blood cells. The abnormal accumulation of non-malignant lymphocytes can lead to splenomegaly, lymphadenopathy, an increased risk of malignancy, and an autoimmune cytopenia resulting in anemia and thrombocytopenia. In ALPS there is an increase in the CD4- CD8- TCR alpha beta+ T cells, FAS ligand (FAS-L), and IL-10 protein. CD4-CD8- T cells are also known as double negative T cells (DNT). The expression of an atypical isoform of CD45 called CD45R (also known as B220) on CD4-CD8-TCR alpha beta+ T cells is sensitive and specific for ALPS. PMID: 19176318 PMID: 11513545 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Cells.CD4-CD8-CD45R+TCR alpha beta+
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2017-10-04
- Construct for LOINC Short Name
- Cell.DNT-CD45R+TCRa b
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP263674-6
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | células.CD4-CD8-CD45R+TCR alfa beta+ |
| it-IT | Italian (Italy) | Cellule.CD4-CD8-CD45R+TCR alpha beta+ |
| zh-CN | Chinese (China) | 细胞.CD4-CD8-CD45R+TCR alpha beta+ Synonyms: 细胞.CD4-CD8-CD45R+TCR αβ+; |
| pl-PL | Polish (Poland) | Komórki.CD4-CD8-CD45R+TCR alfa beta+ Synonyms: Komórki CD4-CD8-CD45R+TCR alfa beta+ |
LOINC Copyright
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