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Description

Autoimmune lymphoproliferative syndrome (ALPS) is a disorder that occurs when a mutation in the FAS gene prevents the normal death cycle of the lymphocytic white blood cells. The abnormal accumulation of non-malignant lymphocytes can lead to splenomegaly, lymphadenopathy, an increased risk of malignancy, and an autoimmune cytopenia resulting in anemia and thrombocytopenia. In ALPS there is an increase in the CD4- CD8- TCR alpha beta+ T cells, FAS ligand (FAS-L), and IL-10 protein. CD4-CD8- T cells are also known as double negative T cells (DNT). The expression of an atypical isoform of CD45 called CD45R (also known as B220) on CD4-CD8-TCR alpha beta+ T cells is sensitive and specific for ALPS. PMID: 19176318 PMID: 11513545 Source: Regenstrief LOINC

Basic Part Properties

Part Name
Cells.CD4-CD8-CD45R+TCR alpha beta+
Part Display Name
Cells.CD4-CD8-CD45R+TCR alpha beta+
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-10-04
Construct for LOINC Short Name
Cell.DNT-CD45R+TCRa b

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP263674-6

Language Variants Get Info

TagLanguageTranslation
es-ESSpanish (Spain)células.CD4-CD8-CD45R+TCR alfa beta+
it-ITItalian (Italy)Cellule.CD4-CD8-CD45R+TCR alpha beta+
zh-CNChinese (China)细胞.CD4-CD8-CD45R+TCR alpha beta+
Synonyms: 细胞.CD4-CD8-CD45R+TCR αβ+;细胞.CD4-CD8-CD45R+T细胞受体αβ+;细胞.CD4-CD8-CD45R+T-细胞受体αβ+
fr-FRFrench (France)CD4-CD8-CD45RA+TCR alpha bêta+
pl-PLPolish (Poland)Komórki.CD4-CD8-CD45R+TCR alfa beta+
Synonyms: Komórki CD4-CD8-CD45R+TCR alfa beta+
el-GRGreek (Greece)Κύτταρα.CD4-CD8-CD45R+TCR α β+
Synonyms: Κύτταρα.CD4-CD8-CD45R+TCR α β+