Version 2.78

Description

Helicobacter pylori (H.pylori) are gram-negative bacterium usually found in the stomach. To treat for H.pylori infections, antibiotics such as clarithromycin/metronidazole or clarithromycin/amoxicillin are given. H.pylori is known to be resistant to clarithromycin due to decreased binding of the antibiotic to the bacterial ribosome. The insufficient binding is caused by point mutations within the 23S rRNA peptidyl transferase -encoding region. Three major variants (A2143G, A2142G and A2142C) in two adjacent position on the 23S rRNA gene are most commonly associated with clarithromycin resistance. The A2143G variant is most frequently reported, whereas variants A2142G and A2142C are less common. Various molecular assays have been developed to detect CLR resistance in H. pylori isolates in both gastric biopsy and stool specimens. PMID: 27436390 Source: Regenstrief LOINC

Basic Part Properties

Part Name
Helicobacter pylori 23S rRNA clarithromycin resistance mutation
Part Display Name
Helicobacter pylori 23S rRNA clarithromycin resistance mutation
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-12-19
Construct for LOINC Short Name
H pylori 23S rRNA clarith res

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP265289-1

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Helicobacter pylori, mutazione 23S rRNA resistenza alla claritromicina
zh-CN Chinese (China) 幽门螺杆菌 23S rRNA 克拉霉素耐药性突变
Synonyms: 幽门螺杆菌（幽门弯曲菌、Hp） 23S rRNA 克拉霉素耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变
es-ES Spanish (Spain) Mutación 23S RNA de resistencia a claritromicina en Helicobacter pylori