Version 2.80

Description

Von Willebrand disease (VWD) is caused by either a qualitative or quantitative deficit of the multimeric glycoprotein known as von Willebrand factor (VWF). VWD affects 1-2% of the world population, making it the most common inherited bleeding disorder. VWF plays a crucial role in primary hemostasis by triggering platelet adhesion to injured vessel walls and promoting platelet aggregation. VWF also protects factor VIII from premature degradation in the peripheral circulation. To diagnose VWD, there are several tests that must be run including ristocetin cofactor activity, VWF antigen quantitative assay, Factor VIII activity, and collagen binding assay. Additional tests are needed to determine the subtype of VWD. The ristocetin cofactor activity can be measured using platelet aggregation or platelet agglutination. Both of these assays measure the agglutination of platelets by VWF in the presence of ristocetin. When anti-VWF antibodies bind to the epitope of VWF the ability of VWF to aggregate platelets to the area of injury is compromised. Patients who are most likely to develop anti-VWF include patients with complete or partial VWF gene deletions, patients who have received multiple transfusions, and patients with a family history of developing anti-VWF antibodies. PMID: 28804849 PMID: 21186048 PMID: 23297130 Source: Regenstrief LOINC

Basic Part Properties

Part Name
von Willebrand factor.ristocetin cofactor inhibitor
Part Display Name
von Willebrand factor.ristocetin cofactor inhibitor
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-03-01
Construct for LOINC Short Name
vWF.ristocetin cofactor inhibitor

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP266352-6

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) von Willebrand, fattore.inibitore cofattore ristocetina
Synonyms: Inibitore del cofattore ristocetina del fattore di
zh-CN Chinese (China) von Willebrand 因子.瑞斯托菌素辅助因子抑制剂
Synonyms: von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）.瑞斯托菌素辅助因子（利托菌素辅助因子、瑞斯托菌素辅因子、瑞斯托霉素辅助因子、瑞斯西丁素辅助因子、Ristocetin 因子） 抑制剂（抑制因子、抑制物）
es-ES Spanish (Spain) Factor Von Willebrand. Cofactor inhibidor de ristocetina
el-GR Greek (Greece) παράγοντας Von Willebrand.αναστολέας συμπαράγοντα ριστοσετίνης
Synonyms: παράγοντας Von Willebrand.αναστολέας συμπαράγοντα ριστοσετίνης