Version 2.78

Description

Cells expressing CD45 (CD45+) in the absence of CD3 (CD3-) are used as an initial gating population for identifying natural killer (NK) cells. In addition to CD3-, a majority of NK cells are further gated on the expression of CD56 (neural cell adhesion molecule) and CD16 (low-affinity IgG Fc receptor-FcgammaRIII) cell surface markers. However, NK cells are not a homogeneous population since not all NK cells express the CD56 and CD16 markers uniformly. PMID: 17920947 NK cells that express CD56+ and are CD16- are called regulatory or cytokine secreting NK cells, whereas NK cells that express CD16+ and are CD56+/- (dim or negative) are referred to as cytotoxic NK cells. PMID: 19278419 NK cell deficiencies may be present in various primary (monogenic) immunodeficiencies (e.g.autoimmune lymphoproliferative syndrome (ALPS), familial hemophagocytic lymphohistiocytosis (FHL), Hermansky-Pudlak syndrome, Papillon-Lefevre syndrome, severe combined immunodeficiencies) or in isolated NK cell deficiency (e.g. absolute NK cell deficiency (ANKD), the classic NK cell deficiency (CNKD), and the functional NK cell deficiency (FNKD)). PMID: 17088643 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
CD3-CD45+ cells
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-04-26
Construct for LOINC Short Name
CD3-CD45+ cells

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP266960-6

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Cellule.CD3-CD45+
Synonyms: Cellule CD3-CD45+
zh-CN Chinese (China) 细胞.CD3-CD45+
es-ES Spanish (Spain) Células CD3-CD45+