Version 2.78

Description

Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays. Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Natural killer cell cytotoxicity.IL-stimulated 1.88:1 effector to target cell ratio
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-07-18
Construct for LOINC Short Name
NK cyto IL2 1.88:1 E:T

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP268100-7

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 1.88: 1
zh-CN Chinese (China) 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 1.88:1
Synonyms: 自然杀伤细胞（NK细胞）细胞毒性.IL-2（白细胞介素 2、白介素 2） 刺激型（刺激法） 效应细胞/靶细胞比（比率、比值） 1.88:1
it-IT Italian (Italy) Cellula natural killer, citotossicità. rapporto IL-2 stimolato 1.88:1 effettore verso cellula target
Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 1.88:1 effettore verso cellula target