LP268509-9
Erythrocytes.CD59 complete loss
Active
Description
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.[https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html] CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Erythrocytes.CD59 complete loss
- Part Display Name
- Erythrocytes.CD59 complete loss
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2018-09-07
- Construct for LOINC Short Name
- RBCs CD59- comp loss
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Pérdida completa de eritrocitos CD59 |
| it-IT | Italian (Italy) | Eritrociti.perdita completa CD59 Synonyms: RBC perdita completa CD59 |
| zh-CN | Chinese (China) | 红细胞.CD59 完全丧失 Synonyms: CD59 完全丧失型红细胞; |
| pl-PL | Polish (Poland) | Erytrocyty CD59 ujemne |
| el-GR | Greek (Greece) | Ερυθροκύτταρα.πλήρης απώλεια CD59 Synonyms: Ερυθροκύτταρα.πλήρης απώλεια CD59 |
LOINC Copyright
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