Version 2.77

Descriptions

Docosapentaenoic acid designates any straight chain 22:5 fatty acid. Two isomers are of particular interest

all-cis-7,10,13,16,19-docosapentaenoic acid is an ω-3 fatty acid with the trivial name clupanodonic acid, commonly called DPA. It is an intermediary between eicosapentaenoic acid (EPA, 20:5 ω-3) and docosahexaenoic acid (DHA, 22:6 ω-3). Seal oil is a rich source.

all-cis-4,7,10,13,16-docosapentaenoic acid is an ω-6 fatty acid with the trivial name Osbond acid. It is formed by an elongation and desaturation of arachidonic acid 20:4 ω-6. In mammals, clupanodonic acid deficiency is accompanied by an increase of this isomer; the Osbond/DHA ratio is thus a marker of dietary DHA sufficiency Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Eicosapentaenoate (EPA) is a long chain omega-3 fatty acid that is present throughout the body including in cell membranes. EPA is found in fatty fish including salmon, tuna, mackerel, sardines, shellfish, and herring. EPA can be biosynthesized from alpha-linolenic acid (ALA), but it is much more efficient to increase levels by including EPA-rich sources in one's diet. EPA has anti-inflammatory properties that are vital to fetal development and the process of healthy aging. Its anti-inflammatory effects are due to reduced gene expression of genes involved in inflammatory and atherogenesis-related pathways, thereby lowering the risk of cardiovascular disease. EPA has also been found to increase platelet stability, decrease endothelial activation, and improve vascular permeability. Taking EPA supplements leads to an increased amount of EPA in the plaque of carotid arteries which may decrease inflammation and increase plaque stability. PMID: 22332096 Many other studies have been run that show acorrelation between higher plasma levels of EPA and reduced symptoms of disease, some of which include Alzheimer's disease, depression, rheumatoid arthritis, and Raynaud Syndrome.[ http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000301] Source: Regenstrief LOINC

Docosahexaenoate (DHA) is one of the essential polyunsaturated omega-3 fatty acids that is primarily obtained by ingesting fatty fish including salmon, mackerel, tuna, herring, and sardines.[https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/] There are many benefits derived from eating healthy levels of DHA including a reduction of chronic inflammation, atherosclerosis, hypertension, arthritis, depression, adult-onset diabetes mellitus, myocardial infarction, thrombosis, and some cancers. DHA is important in brain development of infants and in maintaining normal brain function in adults. Studies have demonstrated that infants who drink DHA-fortified formula have higher visual acuity than infants who drink unfortified formula. Deficiencies of DHA have been associated with fetal alcohol syndrome, attention deficit hyperactivity disorder, cystic fibrosis, phenylketonuria, unipolar depression, aggressive hostility, adrenoleukodystrophy, cognitive decline in aging individuals, and the onset of sporadic Alzheimer's disease. Patients who consume 200 mg/day of DHA have a 50% reduction in the incidence of sudden cardiac arrest. PMID: 10479465 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Eicosapentaenoate (C20:5w3)+Docosapentaenate (C22:5w3)+Docosahexaenoate (C22:6w3)
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-10-20
Construct for LOINC Short Name
EPA+DPA+DHA

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP269615-3

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 二十碳五烯酸+二十二碳五烯酸 w3+二十二碳六烯酸
Synonyms: 二十碳五烯酸（二十碳五烯酸酯或盐）+二十二碳五烯酸 w3（C22:5w3、DPA、二十二碳五烯酸、二十二碳五烯酸, C22:5w3）+二十二碳六烯酸（DHA、C22:6w3、二十二碳六烯酸 w3）
es-ES Spanish (Spain) Eicosapentaenoico + Docosapentaenoico w3 + Docosahexaenoico
it-IT Italian (Italy) Eicosapentaenoato+Docosapentaenate w3+Docosaesaenoato