Version 2.77

Description

Many drugs are metabolized by members of the cytochrome P450 CYP3A subfamily, which present considerable variation in gene expression. CYP3A4, CYP3A5, CYP3A7 and CYP3A43 genes are included in the 231-kb CYP3A locus. Several single nucleaotide polymorphisms (SNPs) with the CYP3A5 are associated with absence of CYP3A5 expression in the liver. The CYP3A5*1 allele (A6986) appears to be the main allele associated with CYP3A5 expression and activity. Individuals with a CYP3A5*1 allele may show more rapid than average metabolism of CYP3A substrates. Carriers of the mutation CYP3A5*3 (A6986G) appear not to express the enzyme due to the creation of a cryptic splice site. Since CYP3A5 expression in the liver is likely to be a useful predictor of metabolism of a variety of drugs, PCR-based assays are performed to identify a patient's genotype for the CYP3A5*1 and CYP3A5*3 alleles. Source: Regenstrief LOINC, PMID: 12814460

Basic Part Properties

Part Display Name
CYP3A7 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-01-14
Construct for LOINC Short Name
CYP3A7

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP281375-8

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) CYP3A7 基因
Synonyms: 细胞色素 P450 家族 3 亚家族 A 成员 7;细胞色素 P450, 家族 3, 亚家族 A, 多肽 7;细胞色素 P450, 亚家族 IIIA, 多肽 7;细胞色素 P450-HFLA;细胞色素 P450 3A7;黄素蛋白连接单加氧酶;黄酶连接单加氧酶;黄素蛋白单加氧酶;黄酶单加氧酶;芳基烃羟化酶;芳烃羟化酶;微粒体单加氧酶;异生物单加氧酶;外源性化学物单加氧酶;异生物质单加氧酶;Cytochrome P450 Family 3 Subfamily A Member 7;Cytochrome P45
it-IT Italian (Italy) CYP3A7, gene
nl-NL Dutch (Netherlands) CYP3A7-gen
es-ES Spanish (Spain) Gen CYP3A7