LP28446-0
BCL2
Active
Descriptions
BCL-2 immunopositivity has been linked to the emergence of androgen independence in metastatic prostate cancer. Source: Regenstrief Institute
Bcl-2 (B-cell lymphoma 2) is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Bcl-2 orthologs have been identified in numerous mammals for which complete genome data are available. The two isoforms of Bcl-2, Isoform 1, also known as 1G5M, and Isoform 2, also known as 1G5O/1GJH, exhibit similar fold. However, results in the ability of these isoforms to bind to the BAD and BAK proteins, as well as in the structural topology and electrostatic potential of the binding groove, suggest differences in antiapoptotic activity for the two isoforms.
The Bcl-2 gene has been implicated in a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung carcinomas, as well as schizophrenia and autoimmunity. It is also thought to be involved in resistance to conventional cancer treatment. This suggests that decreased apoptosis may play a role in the development of cancer.
Antibodies to Bcl-2 can be used with immunohistochemistry to identify cells containing the antigen. In healthy tissue, these antibodies will react with B-cells in the mantle zone, as well as some T-cells. However, there is a considerable increase in positive cells in follicular lymphoma, as well as many other forms of cancer. In some cases, the presence or absence of Bcl-2 staining in biopsies may be significant for the patient's prognosis or likelihood of relapse.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- BCL2
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2001-05-14
- Construct for LOINC Short Name
- BCL2
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | BCL2 Synonyms: BCL-2; |
| fr-CA | French (Canada) | BCL2 |
| et-EE | Estonian (Estonia) | BCL2 |
| es-ES | Spanish (Spain) | BCL2 |
| it-IT | Italian (Italy) | BCL2 |
| tr-TR | Turkish (Turkey) | BCL2 |
| ru-RU | Russian (Russian Federation) | BCL2 |
| nl-NL | Dutch (Netherlands) | BCL2 |
| fr-BE | French (Belgium) | BCL2 |
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