Version 2.78

Description

N-Acetylaspartic acid, or N-acetylaspartate (NAA), is a derivative of aspartic acid with a formula of C6H9NO5 and a molecular weight of 175.139.

NAA is the second-most-concentrated molecule in the brain after the amino acid glutamate. It is synthesized in neurons from the amino acid aspartic acid and acetyl-coenzyme A. The various functions served by NAA are still under investigation, but the primary proposed functions include its being:

1.A neuronal osmolyte that is involved in fluid balance in the brain
2.A source of acetate for lipid and myelin synthesis in oligodendrocytes, the glial cells that myelinate neuronal axons
3.A precursor for the synthesis of the important neuronal dipeptide N-Acetylaspartylglutamate
4.A contributor to energy production from the amino acid glutamate in neuronal mitochondria.
In the brain, NAA is thought to be present predominantly in neuronal cell bodies, where it acts as a neuronal marker. NAA gives off the largest signal in magnetic resonance spectroscopy of the human brain, and the levels measured there are decreased in numerous neuropathological conditions ranging from brain injury to stroke to Alzheimer's disease. This fact makes NAA a reliable diagnostic molecule for doctors treating patients with brain damage or disease.

NAA may also be a marker of creativity. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Basic Part Properties

Part Display Name
N-acetylaspartate
Part Type
Component (Describes the core component or analyte measured)
Created On
2001-08-27
Construct for LOINC Short Name
N-Ac-Asp

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP28524-4
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https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP28524-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) N-乙酰天门冬氨酸
Synonyms: N-Ac-Asp;NASP;N-乙酰天冬氨酸;N-乙酰门冬氨酸;氮-乙酰基天门冬氨酸
fr-CA French (Canada) N-acétylspartate
et-EE Estonian (Estonia) N-atsetüülaspartaat
es-ES Spanish (Spain) N-acetilaspartato
it-IT Italian (Italy) N-acetilaspartato
tr-TR Turkish (Turkey) N-asetilaspartat
ru-RU Russian (Russian Federation) N-ацетиласпартат
nl-NL Dutch (Netherlands) N-acetylaspartaat
fr-BE French (Belgium) N-acétylspartate