Version 2.78

Description

DNA index (DI), which is associated with DNA ploidy, is a reflection of the average amount of DNA in the tumor cells. The DI can be measured by flow cytometry or image cytometry, both of which result in a DNA ploidy histogram, where the channel number on the x-axis represents fluorescent intensity or optical density for the two methods, respectively. All cells with the same quantity of DNA form one peak on the histogram, and with a population of normal cells, the largest peak represents diploid cells in G1 of the cell cycle, and a smaller peak represents cells in G2/M-phase. When there is a mixed population of normal and tumor cells, two or more G1 peaks will be seen, one for the normal cells and one or more for the tumor cells. The DI is calculated by dividing the channel number of the tumor cell G1 peak by the channel number of the normal (diploid control) G1 peak. If the tumor cells are diploid, the DI is 1, and if the cells are aneuploid, the DI is greater than or less than 1. For example, tetraploid cells have a DI of 2 because they have twice as much DNA content as normal diploid cells, and hypodiploid tumor cells have a DI of <1. PMID: 24532190 Source: Regenstrief LOINC, PMID: 24532190

Basic Part Properties

Part Display Name
DNA index
Part Type
Component (Describes the core component or analyte measured)
Created On
2002-02-27
Construct for LOINC Short Name
DNA Index

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP28735-6

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) DNA 指数
Synonyms: DI;DNA 指数 = 肿瘤 G1 峰的平均通道数（mean channel #）与正常细胞平均通道数之比;DNA 指数（DNA index，DI）
es-ES Spanish (Spain) Índice del ADN
it-IT Italian (Italy) DNA, indice
Synonyms: Indice di DNA
tr-TR Turkish (Turkey) DNA indeksi
ru-RU Russian (Russian Federation) ДНК индекс
Synonyms: ДНК отношение
nl-NL Dutch (Netherlands) DNA index