Version 2.78

Descriptions

Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene.

Interleukin-8 is often associated with inflammation. As an example, it has been cited as a proinflammatory mediator in gingivitis and psoriasis. The fact that Interleukin-8 secretion is increased by oxidant stress and conversely, Interleukin-8, by causing recruitment of inflammatory cells induces a further increase in oxidant stress mediators, makes it a key parameter in localized inflammation.

If a pregnant mother has high levels of interleukin-8, there is an increased risk of schizophrenia in her offspring. High levels of Interleukin 8 have been shown to reduce the likelihood of positive responses to antipsychotic medication in schizophrenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 8 is a 6,000 - 8000 molecular weight glycoprotein produced primarily by macrophages and monocytes. Its primary target cells are neutrophils. Interleukin 8 is a chemotactic agent for monocytes and neutrophils. Interleukin 8 causes oxygen radical and enzyme release by neutrophils and mobilizes products into circulation. Interleukin 8 is stimulated by Interleukin 1 and Tumor Necrosis Factor. Source: Inter Science Institute, Inter Science Institute

Basic Part Properties

Part Display Name
Interleukin 8
Part Type
Component (Describes the core component or analyte measured)
Created On
2002-11-19
Construct for LOINC Short Name
Il8

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP30829-3

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 白细胞介素 8
Synonyms: Il8;IL-8;嗜中性粒细胞激活因子;嗜中性粒细胞激活肽, 单核细胞源性;嗜中性粒细胞激活肽, 成纤维细胞细胞源性;嗜中性粒细胞激活肽, 淋巴细胞源性;白介素 8;白介素-8;白细胞介素-8;白细胞粘附抑制剂;白细胞黏附抑制剂;趋化因子, 嗜中性粒细胞;趋化因子, 嗜中性粒细胞, 单核细胞源性;趋化因子, 巨噬细胞源性;阴离子嗜中性粒细胞激活肽
fr-CA French (Canada) Interleukine 8
et-EE Estonian (Estonia) Interleukiin 8
es-ES Spanish (Spain) Interleucina 8
it-IT Italian (Italy) Interleuchina 8
tr-TR Turkish (Turkey) İnterlökin 8
ru-RU Russian (Russian Federation) Интерлейкин 8
nl-NL Dutch (Netherlands) interleukine 8
fr-BE French (Belgium) Interleukine 8
Synonyms: IL 8