LP31855-7
BRCA2 gene
Active
Description
The BRCA2 gene (breast cancer 2, early onset) [HGNC Gene ID:1101] is located on chromosome 13q12.3. Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008] [NCBI Gene ID:675] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Display Name
- BRCA2 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2003-07-28
- Construct for LOINC Short Name
- BRCA2 gene
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Language Variants Get Info
Tag | Language | Translation |
---|---|---|
zh-CN | Chinese (China) | BRCA2 基因 Synonyms: Ashkenazi 犹太人群全面身体检查; |
et-EE | Estonian (Estonia) | BRCA2 geen |
es-ES | Spanish (Spain) | Gen BCRA2 |
it-IT | Italian (Italy) | BRCA2, gene Synonyms: Gene BRCA2 |
tr-TR | Turkish (Turkey) | BRCA2 geni |
ru-RU | Russian (Russian Federation) | BRCA2 ген |
nl-NL | Dutch (Netherlands) | BRCA2-gen Synonyms: BRCA2 gen |
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