LP32459-7
von Willebrand factor cleaving protease inhibitor
Active
Description
von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. PMID: 18756543 Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- von Willebrand factor cleaving protease inhibitor
- Part Display Name
- von Willebrand factor (vWf) cleaving protease inhibitor
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2003-09-12
- Construct for LOINC Short Name
- vWF Cp Inhib
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | von Willebrand 因子裂解蛋白酶抑制剂 Synonyms: von Willebrand 因子（vWf 因子、 |
| es-ES | Spanish (Spain) | Inhibidor de la proteasa divisora del Factor de von Villebrand |
| it-IT | Italian (Italy) | von Willebrand, inibitore proteasi di taglio fattore Synonyms: Inibitore di proteasi di taglio del fattore di von |
| tr-TR | Turkish (Turkey) | von Willebrand faktörü parçalıyıcı proteaz inhibitörü |
| ru-RU | Russian (Russian Federation) | von Willebrand (vWf) расщепляющая протеаза ингибитор |
| fr-BE | French (Belgium) | Inhibiteur de la protéase de coupage Facteur von Willebrand |
| fr-CA | French (Canada) | Inhibiteur de la protéase clivage du Facteur von Willebrand |
| nl-NL | Dutch (Netherlands) | von Willebrand-factor cleaving protease inhibitor |
| el-GR | Greek (Greece) | αναστολέας πρωτεάσης διάσπασης παράγοντα Von Willebrand Synonyms: αναστολέας πρωτεάσης διάσπασης παράγοντα Von Willebrand |
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