LP33554-4
14-3-3 protein
Active
Descriptions
14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 100 signaling proteins have been reported as 14-3-3 ligands. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis by Moore and Perez. Elevated amounts of 14-3-3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia
The 14-3-3 protein is a highly conserved family of proteins that was originally found in brain tissue in 1968. There are seven isoforms of 14-3-3 protein in mammals which are found in all eukaryotic cells. The proteins weigh between 25 and 30 kilo Daltons and interact with more than 200 target proteins. 14-3-3 proteins are able to easily move between the cytoplasm and the nucleus but are mainly found in the cytoplasm. 14-3-3 is an important regulator of cellular function including controlling the cycle of the cell, cell growth, differentiation, survival, apoptosis, migration and spreading. The isoform 14-3-3o is believed to have a role in human cancer development. PMID: 15857577 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- 14-3-3 protein
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2004-05-11
- Construct for LOINC Short Name
- 14-3-3 protein
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 14-3-3 蛋白 Synonyms: Creutzfeldt-Jacob 病; |
| fr-CA | French (Canada) | Protéine 14-3-3 |
| et-EE | Estonian (Estonia) | 14-3-3 valk |
| es-ES | Spanish (Spain) | Proteína 14-3-3 |
| it-IT | Italian (Italy) | 14-3-3, proteina Synonyms: Proteina 14-3-3 |
| tr-TR | Turkish (Turkey) | 14-3-3 protein |
| ru-RU | Russian (Russian Federation) | 14-3-3 протеин Synonyms: 14-3-3 белок |
| nl-NL | Dutch (Netherlands) | 14-3-3 eiwit |
| fr-BE | French (Belgium) | Protéine 14-3-3 |
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