LP343939-7
Alpha globin gene cluster & HS-40 region
Active
Description
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5 '- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008] [NCBI Gene ID:3039] Source: National Center for Biotechnology Information (NCBI) Books
Basic Part Properties
- Part Name
- Alpha globin gene cluster & HS-40 region
- Part Display Name
- Alpha globin gene cluster and HS-40 region
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2019-05-03
- Construct for LOINC Short Name
- Alpha globin genes + HS-40
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | Alpha 珠蛋白基因簇 & HS-40 区域 Synonyms: α珠蛋白基因簇 & HS-40 区域 |
| it-IT | Italian (Italy) | cluster genico alfa globina & regione HS-40 Synonyms: cluster genico della alfa globina e regione HS-40 |
| es-ES | Spanish (Spain) | Grupo de genes de alfa globina y región HS-40 |
| el-GR | Greek (Greece) | Σύμπλεγμα γονιδίου α σφαιρίνης & περιοχή HS-40 Synonyms: Σύμπλεγμα γονιδίου α σφαιρίνης & περιοχή HS-40 |
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