LP344998-2

F10 gene

Active

Description

The F10 gene encodes for factor X, a vitamin K-dependent protein of the blood coagulation cascade synthesized in the liver. Factor X is the first component of the final common coagulation pathway and is activated to Xa by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway). The activated factor Xa is then involved in cleaving prothrombin into active thrombin. Mutations in the F10 gene cause a rare bleeding disorder of variable severity known as factor X deficiency, with severe cases resulting from homozygous or compound heterozygous mutations, and mild /moderate cases are more commonly heterozygous. Clinical presentations range from nose bleeds, menorrhagia or post-surgical bleeding in the mild cases to hematuria, hematomas, Gi bleeding, bleeding into joints or tissues in more severe cases. Unlike the X-linked hemophilias, F10 is located on chromosome 13 so occurs equally in both sexes. Treament involves factor replacement. PMID: 30507709 Source: Regenstrief LOINC

Basic Part Properties

Part Name

F10 gene

Part Display Name

F10 gene

Part Type

Component (Describes the core component or analyte measured)

Created On

2019-05-14

Construct for LOINC Short Name

F10 gene

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.

CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP344998-2

Language Variants Get Info

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.