LP34971-9
LITAF gene
Active
Description
The LITAF gene (lipopolysaccharide-induced TNF factor) [HGNC Gene ID:16841] is located on chromosome 16p13.13. Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014] [NCBI Gene ID:9516] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Name
- LITAF gene
- Part Display Name
- LITAF gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-01-03
- Construct for LOINC Short Name
- LITAF gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | LITAF 基因 Synonyms: Charcot-Marie Tooth 病, 1C 型; |
| es-ES | Spanish (Spain) | Gen LITAF |
| it-IT | Italian (Italy) | LITAF, gene Synonyms: Gene LITAF |
| et-EE | Estonian (Estonia) | LITAF geen |
| tr-TR | Turkish (Turkey) | LITAF geni |
| ru-RU | Russian (Russian Federation) | LITAF ген |
| nl-NL | Dutch (Netherlands) | LITAF-gen Synonyms: LITAF gen |
| el-GR | Greek (Greece) | Γονίδιο LITAF Synonyms: Γονίδιο LITAF |
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