LP35572-4
NOD2 gene
Active
Description
The NOD2 gene (nucleotide-binding oligomerization domain containing 2) [HGNC Gene ID:5331] is located on chromosome 16q21. This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014] [NCBI Gene ID:64127] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Name
- NOD2 gene
- Part Display Name
- NOD2 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-03-29
- Construct for LOINC Short Name
- NOD2 gene
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP35572-4 - ConceptMap translate
- https:
//fhir.loinc.org/ConceptMap/$translate?system=http: //loinc.org&code=LP35572-4
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CARD15 基因 Synonyms: ACUG; |
| es-ES | Spanish (Spain) | Gen CARD15 |
| it-IT | Italian (Italy) | NOD2, gene Synonyms: Gene NOD2 |
| et-EE | Estonian (Estonia) | NOD2 geen |
| tr-TR | Turkish (Turkey) | NOD2 geni |
| ru-RU | Russian (Russian Federation) | NOD2 ген |
| nl-NL | Dutch (Netherlands) | NOD2-gen Synonyms: NOD2 gen |
| el-GR | Greek (Greece) | Γονίδιο NOD2 Synonyms: Γονίδιο NOD2 |
LOINC Copyright
Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://