LP35576-5
TNFRSF1A gene
Active
Description
The TNFRSF1A gene (tumor necrosis factor receptor superfamily, member 1A) [HGNC Gene ID:11916] is located on chromosome 12p13.2. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] [NCBI Gene ID:7132] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Display Name
- TNFRSF1A gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-03-30
- Construct for LOINC Short Name
- TNFRSF1A gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | TNFRSF1A 基因 Synonyms: CD120a 基因; |
| et-EE | Estonian (Estonia) | TNFRSF1A geen |
| es-ES | Spanish (Spain) | Gen TNFRSF1A |
| it-IT | Italian (Italy) | TNFRSF1A, gene Synonyms: Gene TNFRSF1A |
| tr-TR | Turkish (Turkey) | TNFRSF1A geni |
| ru-RU | Russian (Russian Federation) | TNFRSF1A ген |
| nl-NL | Dutch (Netherlands) | TNFRSF1A-gen Synonyms: TNFRSF1A gen |
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