LP35594-8
Thyroid transcription factor 1
Active
Description
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon. It is also known as thyroid specific enhancer binding protein. It is used in anatomic pathology as a marker to determine if a tumor arises from the lung or thyroid.
TTF-1 positive cells are found in the lung as type II pneumocytes and Clara cells. In the thyroid, follicular and parafollicular cells are also positive for TTF-1.
For lung cancers, adenocarcinomas are usually positive, while squamous cell carcinomas and large cell carcinomas are rarely positive. Small cell carcinomas (of any primary site) are usually positive. TTF1 is more than merely a clinical marker of lung adenocarcinoma. It plays an active role in sustaining lung cancer cells in view of the experimental observation that it is mutated in lung cancer. TTF-1 staining is often positive in pulmonary adenocarcinomas, large cell carcinomas, small-cell lung carcinomas, neuroendocrine tumors other than small-cell lung carcinomas and extrapulmonary small-cell carcinomas. It is also positive in thyroid cancers and is used for monitoring for metastasis and recurrence.
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Source: Wikipedia
, Wikipedia
Basic Part Properties
- Part Name
- Thyroid transcription factor 1
- Part Display Name
- Thyroid transcription factor 1
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-04-05
- Construct for LOINC Short Name
- TTF1
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 甲状腺转录因子 1 Synonyms: TTF1; |
| es-ES | Spanish (Spain) | Factor 1 de transcripción tiroideo |
| it-IT | Italian (Italy) | Tiroide, fattore 1 di trascrizione Synonyms: Fattore 1 di trascrizione tiroideo |
| tr-TR | Turkish (Turkey) | Tiroid transkripsiyon faktörü 1 |
| ru-RU | Russian (Russian Federation) | Тиреоидный фактор транскрипции 1 |
| fr-BE | French (Belgium) | Thyroïd transcription facteur 1 |
| fr-CA | French (Canada) | Thyroïdotranscription facteur 1 |
| nl-NL | Dutch (Netherlands) | thyroïd transcriptiefactor 1 Synonyms: thyroid transcriptiefactor 1 |
| el-GR | Greek (Greece) | Μεταγραφικός παράγοντας 1 του θυρεοειδούς Synonyms: Μεταγραφικός παράγοντας 1 του θυρεοειδούς |
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