Version 2.78

Description

The PDCD10 gene (programmed cell death 10) [HGNC Gene ID:8761] is located on chromosome 3q26.1. This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] [NCBI Gene ID:11235] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type Source Reference
Webcontent Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Link to OMIM

Basic Part Properties

Part Display Name
PDCD10 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2005-07-14
Construct for LOINC Short Name
PDCD10 gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP35891-8
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) PDCD10 基因
Synonyms: CCM3;MGC1212;MGC24477;TFAR15;凋亡相关蛋白 15 基因;程序性细胞死亡 10;细胞程序化死亡 10;脑海绵状血管畸形 3;脑海绵状血管瘤 3;颅内海绵状血管畸形
et-EE Estonian (Estonia) PDCD10 geen
es-ES Spanish (Spain) Gen PDCD10
it-IT Italian (Italy) PDCD10, gene
Synonyms: Gene PDCD10
tr-TR Turkish (Turkey) PDCD10 geni
ru-RU Russian (Russian Federation) PDCD10 ген
nl-NL Dutch (Netherlands) PDCD10-gen
Synonyms: PDCD10 gen