Version 2.78

Description

In oncology, AFP-L3 is an isoform of Alpha-fetoprotein (AFP), a substance typically used in the triple test during pregnancy and for screening chronic liver disease patients for hepatocellular carcinoma (HCC). AFP can be fractionated by affinity electrophoresis into 3 glycoforms: L1, L2, and L3 based on the reactivity with the lectin Lens culinaris agglutinin (LCA). AFP-L3 binds strongly to LCA via an additional α 1-6 fucose residue attached at the reducing terminus of N-acetylglucosamine; this is in contrast to the L1 isoform. It is the L1 isoform which is typically associated with non-HCC inflammation of liver disease condition. The L3 isoform is specific to malignant tumors and its detected presence can serve to identify patients whom need increased monitoring for the development of HCC in high risk populations (i.e. chronic hepatitis B & C and/or liver cirrhosis). AFP-L3% is now being considered as a tumor marker for the North American demographic. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Basic Part Properties

Part Display Name
Alpha-1-Fetoprotein L3
Part Type
Component (Describes the core component or analyte measured)
Created On
2005-09-01
Construct for LOINC Short Name
AFP L3

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP36040-1

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) Alpha-1-胎儿球蛋白.L3
Synonyms: A1 胎儿球蛋白 L3;A1 胎儿球蛋白.L3;A1 胎儿球蛋白L3;A1 胎蛋白 L3;A1 胎蛋白.L3;A1 胎蛋白L3;A1-胎儿球蛋白 L3;A1-胎儿球蛋白.L3;A1-胎儿球蛋白L3;A1-胎蛋白 L3;A1-胎蛋白.L3;A1-胎蛋白L3;AFP L3;Alpha 1 胎儿球蛋白 L3;Alpha 1 胎儿球蛋白.L3;Alpha 1 胎儿球蛋白L3;Alpha 1 胎蛋白 L3;Alpha 1 胎蛋白.L3;Alpha 1 胎蛋白L3;Alpha1 胎儿球蛋白 L3;Alpha1 胎儿球
fr-CA French (Canada) Alpha-1-foetoprotéine.L3
et-EE Estonian (Estonia) Alfa-1-fetoproteiin.L3
es-ES Spanish (Spain) Alfa-1-fetoproteina L3
it-IT Italian (Italy) Alfa-1-Fetoproteina L3
Synonyms: Alfa-1-Fetoproteina L3
tr-TR Turkish (Turkey) Alfa-1-Fetoprotein.L3
ru-RU Russian (Russian Federation) Альфа-1-Фетопротеин.L3
nl-NL Dutch (Netherlands) alfa-1-foetoproteïne.L3
fr-BE French (Belgium) Alpha-1-foetoprotéine.L3