LP36214-2
AKT1 gene
Active
Description
The AKT1 gene (v-akt murine thymoma viral oncogene homolog 1) [HGNC Gene ID:391] is located on chromosome 14q32.32. The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] [NCBI Gene ID:207] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Display Name
- AKT1 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-10-21
- Construct for LOINC Short Name
- AKT1 gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | AKT1 基因 Synonyms: MGC99656; |
| et-EE | Estonian (Estonia) | AKT1 geen |
| es-ES | Spanish (Spain) | Gen AKT1 |
| it-IT | Italian (Italy) | AKT1, gene Synonyms: Gene AKT1 |
| tr-TR | Turkish (Turkey) | AKT1 geni |
| ru-RU | Russian (Russian Federation) | AKT1 ген |
| nl-NL | Dutch (Netherlands) | AKT1-gen Synonyms: AKT1 gen |
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