Version 2.77

Description

Adrenal enzyme steroid 21-hydroxylase (P450c21, CYP21A2) lesions lead to faulty synthesis of adrenal cortisol with frequent deficiency of aldosterone. PMID: 8478006 Cytochrome P450c21 is the essential enzyme in the synthesis of cortisol. It converts progesterone and 17 alpha-hydroxyprogesterone to 11-deoxycorticosterone and 11-doxycortisol, respectively, which in turn are needed to synthesize aldosterone and cortisol. There are two CYP21 genes on chromosome 6 that are arranged together. One that is a pseudogene (CYP21A) and one that is a functional gene (CYP21B). It is proposed that gene crossover between CYP21A and CYP21B may be one of the causes of P450c21 deficiency that ultimately leads to congenital adrenal hyperplasia. One in 10,000 births are found to have P450c21 deficiency and is the primary cause of adrenal hyperplasia. PMID: 2233746[http://www.sciencedirect.com/science/article/pii/S0006291X06005924) Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
21-hydroxylase Ab
Part Type
Component (Describes the core component or analyte measured)
Created On
2006-05-09

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP36918-8

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 21-羟化酶抗体
Synonyms: 21-羟化酶 Ab;类固醇 21-单加氧酶 Ab;类固醇 21-单加氧酶抗体;类固醇 21-单氧酶 Ab;类固醇 21-单氧酶抗体;类固醇 21-羟化酶 Ab;类固醇 21-羟化酶抗体
pl-PL Polish (Poland) 21-hydroksylaza Ab
Synonyms: Przeciwciała do 21-hydroksylazy