LP40299-7
ZAP70
Active
Description
ZAP-70 is an abbreviation for Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa). The protein is a member in the protein-tyrosine kinase family. ZAP-70 is normally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling.
ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). DNA analysis has distinguished two major types of CLL, with different survival times. CLL that is positive for the marker ZAP-70 has an average survival of 8 years. CLL that is negative for ZAP-70 has an average survival of more than 25 years. Many patients, especially older ones, with slowly progressing disease can be reassured and may not need any treatment in their lifetimes.
In systemic lupus erythematosis, the Zap-70 receptor pathway is missing and Syk takes its place.
ZAP70 deficiency results in a form of immune deficiency.
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Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- ZAP70
- Part Display Name
- ZAP70
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2006-06-21
- Construct for LOINC Short Name
- ZAP70
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | ZAP70 Synonyms: ZAP-70; |
| fr-CA | French (Canada) | ZAP70 |
| et-EE | Estonian (Estonia) | ZAP70 |
| es-ES | Spanish (Spain) | ZAP70 |
| it-IT | Italian (Italy) | ZAP70 |
| tr-TR | Turkish (Turkey) | ZAP70 |
| ru-RU | Russian (Russian Federation) | ZAP70 |
| nl-NL | Dutch (Netherlands) | ZAP70 |
| fr-BE | French (Belgium) | ZAP70 |
| fr-FR | French (France) | ZAP70 |
| pl-PL | Polish (Poland) | ZAP70 Synonyms: Kinaza ZAP-70 |
| el-GR | Greek (Greece) | ZAP70 Synonyms: ZAP70 |
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