Version 2.78

Description

Fibroblast growth factor 23, or FGF23, is primarily produced in bone and helps regulate phosphate and vitamin D metabolism by binding to receptors on renal tubular cells. It is produced as a 251-amino acid precursor consisting of a signal peptide, N-terminal domain, and C-terminal domain. The bioactive form of FGF23 consists of the N- and C-terminal domains, after the signal peptide is removed, and is also called the "intact" form. Intact FGF23 is cleaved into N-terminal and C-terminal fragments, which are no longer active, though the C-terminal fragment may compete with intact FGF23 for renal tubule receptors and play a role in regulating overall FGF23 activity. The production of FGF23 is regulated by a variety of factors, including calcium and phosphate levels, 1,25 dihydroxyvitamin D, parathyroid hormone, and iron deficiency. Elevated FGF23 levels are associated with chronic kidney disease as well as cardiovascular disease. PMID: 24269946 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Fibroblast growth factor 23
Part Type
Component (Describes the core component or analyte measured)
Created On
2006-08-21
Construct for LOINC Short Name
FGF-23

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP40488-6

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 成纤维细胞生长因子 23
Synonyms: FGF 23;FGF23;FGF-23;Fibroblast GF 23;伴有高磷血症的家族性肿瘤性普遍性钙质沉着;伴有高磷血症的家族性肿瘤性石未沉着症;伴有高磷血症的家族性肿瘤性钙质沉着;伴有高磷血症的家族性肿瘤性钙质沉着症;伴有高磷酸盐血症的家族性肿瘤性普遍性钙质沉着;伴有高磷酸盐血症的家族性肿瘤性石未沉着症;伴有高磷酸盐血症的家族性肿瘤性钙质沉着;伴有高磷酸盐血症的家族性肿瘤性钙质沉着症;常染色体显性低磷佝偻病;常染色体显性低磷软骨病;常染色体显性低磷酸盐性佝偻症;常染色体显性低磷酸盐性软骨病;纤维
fr-CA French (Canada) Facteur de croissance fibroblaste 23
et-EE Estonian (Estonia) Fibroblastide kasvufaktor 23
es-ES Spanish (Spain) Factor de crecimiento fibroblástico 23
it-IT Italian (Italy) Fibroblasto 23, fattore di crescita
Synonyms: Fattore di crescita del fibroblasto 23
tr-TR Turkish (Turkey) Fibroblast büyüme faktörü 23
ru-RU Russian (Russian Federation) Фибробласт ростовой фактор 23
Synonyms: Фактор роста фибробластов 23
nl-NL Dutch (Netherlands) fibroblast groeifactor 23
fr-BE French (Belgium) Facteur de croissance fibroblaste 23