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Description

The APOA1 gene [HGNC Gene ID:600] is located on chromosome 11 at position q23.3. This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015][NCBI Gene ID:335] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name
APOA1 gene
Part Display Name
APOA1 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-08-21
Construct for LOINC Short Name
APOA1

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Language Variants Get Info

TagLanguageTranslation
zh-CNChinese (China)APOA1 基因
Synonyms: 载脂蛋白 A1 基因;Apolipoprotein A1 gene
it-ITItalian (Italy)APOA1, gene
Synonyms: Gene APOA1
fr-FRFrench (France)APOA1 gène
nl-NLDutch (Netherlands)APOA1-gen
es-ESSpanish (Spain)Gen APOA1
pl-PLPolish (Poland)APOA1 gen
Synonyms: Gen APOA1
el-GRGreek (Greece)Γονίδιο APOA1
Synonyms: Γονίδιο APOA1