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Description

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene [HGNC Gene ID: 2645]. Variations in the SLCO1B1 gene have been significantly associated with a marked increase in systemic exposure to simvastatin and risk of muscle toxicity. PMID: 24918167 The overall effect size and significance of this association are striking for simvastatin compared to other statins. Patients with variations in SLCO1B1 (a transporter of simvastatin) may require a lower simvastatin dose or an alternative statin as compared to patients who do not have this variant. See https://www.pharmgkb.org/gene/PA134865839 for more information and dosing guidelines for drugs impacted by SLCO1B1 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Basic Part Properties

Part Name
SLCO1B1 gene
Part Display Name
SLCO1B1 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-08-23
Construct for LOINC Short Name
SLCO1B1

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Language Variants Get Info

TagLanguageTranslation
zh-CNChinese (China)SLCO1B1 基因
Synonyms: 溶质载体有机阴离子转运蛋白家族成员 1B1 基因;Solute Carrier Organic Anion Transporter Family Member 1B1 gene
it-ITItalian (Italy)SLCO1B1, gene
Synonyms: Gene SLCO1B1
fr-FRFrench (France)SLCO1B1 gène
nl-NLDutch (Netherlands)SLCO1B1-gen
es-ESSpanish (Spain)Gen SLCO1B1
pl-PLPolish (Poland)SLCO1B1 gen
Synonyms: Gen SLCO1B1
el-GRGreek (Greece)Γονίδιο SLCO1B1
Synonyms: Γονίδιο SLCO1B1