Version 2.78

Description

Distinguishing between large B-cell lymphomas is critical because the different forms often require distinct management. Diffuse large B-cell lymphoma (DLBCL) is the most common form, making up 30-40% of all non-Hodgkin's lymphomas. DLBCL is defined pathologically by large neoplastic cells with B-cell derivation and clinically by aggressive presentation, but differs from its former putative subtype, primary mediastinal large B-cell lymphoma (PMBCL), which is believed to arise from thymic medullary B cells. Since 2001, the WHO has recognized PMBCL as a distinct clinicopathologic disease from DLBCL, with likely distinct treatment options. PMBCL accounts for approximately 2% of patients with NHL, and tends to affect younger patients. PMID: 16720849. PMBCL is generally not further subclassified during a patient workup, whereas DLBCL can be further subdivided by cell of origin (COO) into germinal center type and non-germinal center (activated B-cell) type, the latter having significantly worse response to certain treatments PMID: 25135992. Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Large B-cell lymphoma and cell of origin
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-09-17
Construct for LOINC Short Name
Lg B-cell lymph+COO

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP411615-0

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 大B细胞淋巴瘤和细胞起源
Synonyms: 大B细胞淋巴瘤（LBCL）和细胞起源
it-IT Italian (Italy) Linfoma a grandi cellule B e cellula di origine
es-ES Spanish (Spain) Linfoma de células B grandes y células de origen
pl-PL Polish (Poland) Chłoniak z komórek B wg COO
Synonyms: Chłoniak z komórek B wg klasyfikacji Cell of Origin (COO)