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Description

Acetaminophen-cysteine adduct (APAP-CYS) levels are measured in serum or plasma for the determination of liver injury due to acetaminophen-induced hepatotoxicity. PMID: 27641661 The reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is detoxified by glutathione at therapeutic doses. However, when glutathione is depleted, the metabolite covalently binds to cysteine groups on proteins and forms a acetaminophen-cysteine conjugate (3-(cystein-S-yl)-acetaminophen, APAP-CYS), which is thought to lead to hepatotoxicity. PMID: 11901099 Source: LOINC, An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Basic Part Properties

Part Name
Acetaminophen-cysteine adduct
Part Display Name
Acetaminophen-cysteine adduct
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-11-01
Construct for LOINC Short Name
APAP-Cysteine

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP412092-1

Language Variants Get Info

TagLanguageTranslation
zh-CNChinese (China)对乙酰氨基酚-半胱氨酸加合物
Synonyms: 对乙酰氨基酚（扑热息痛、退热净、醋氨酚、醋胺酚）-半胱氨酸（Cys、巯基丙氨酸）加合物（加成物）
it-ITItalian (Italy)Acetaminofene-cisteina, addotto
Synonyms: Addotto di acetaminofene-cisteina
fr-FRFrench (France)Acétaminophène-cystéine adduit
es-ESSpanish (Spain)Aducto de acetaminofeno-cisteína
pl-PLPolish (Poland)Addukt paracetamolu z cysteiną
el-GRGreek (Greece)Προϊόν προσθήκης ακεταμινοφαίνης-κυστεΐνης
Synonyms: Προϊόν προσθήκης ακεταμινοφαίνης-κυστεΐνης