LP417655-0
HLA-DP & DQ & DR (class II) Ab.IgG with prozone effect
Active
Descriptions
HLA antibodies showing the prozone effect represent antibody specificities against HLA antigens that were not apparent in undiluted patient specimen, but became apparent after dilution. This so called prozone effect has been attributed to a number of putative mechanisms, including complement factor, antibody agglutination or competing IgM. Prozone effect can often be reversed with serum dilution or treatment with heat, EDTA, or DTT. Source: Regenstrief LOINC
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.
Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens.
Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- HLA-DP and DQ and DR (class II) IgG with prozone effect
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2020-02-06
- Construct for LOINC Short Name
- HLA classII Ab.IgG prozone
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP417655-0
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | HLA-DP 与 DQ 与 DR (II 类) 抗体.IgG 伴前带效应 Synonyms: HLA-DP 与 DQ 与 DR (II 类) 抗体（Ab）.IgG 伴前带效应; |
| nl-NL | Dutch (Netherlands) | HLA-DP & DQ & DR (klasse II) As.IgG met prozoneffect |
| it-IT | Italian (Italy) | HLA-DP & DQ & DR (classe II) Ab.IgG con effetto prozona Synonyms: HLA-DP e DQ e DR (classe II) Ab.IgG con effetto prozona |
| es-ES | Spanish (Spain) | HLA-DP , DQ , DR (CLASE II) con efecto prozona por Ac IgG |
| pl-PL | Polish (Poland) | HLA-DP & DQ & DR (klasa II) Ab.IgG z efektem prozony Synonyms: Przeciwciała IgG do HLA-DP, DQ i DR (klasa II) z efektem prozony |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright