LP418235-0
UGT1A1 gene.TA repeats
Active
Description
The presence of an additional TA repeat in the TATA region of the UGT1A1 promoter (ie, 7 TA repeats; UGT1A1*28, rs8175347) markedly reduces the level of hepatic bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1), the enzyme necessary for the conjugation of bilirubin. Individuals homozygous for the UGT1A1*28 allele develop Gilbert syndrome, a condition characterized by periods of mild unconjugated hyperbilirubinemia. In addition, individuals positive for the UGT1A1*28 allele are more likely to experience severe adverse effects during irinotecan chemotherapy. Identifying a patient's genotype for the UGT1A1 allele helps determine appropriate starting dosages for irinotecan, reducing the risk of severe toxicity and improving overall therapy. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- UGT1A1 gene.TA repeats
- Part Display Name
- UGT1A1 gene TA repeats
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2020-04-23
- Construct for LOINC Short Name
- UGT1A1 TA
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | UGT1A1 基因.TA 重复序列 |
| fr-FR | French (France) | UGT1A1 gène répétitions TA |
| nl-NL | Dutch (Netherlands) | UGTA1-gen.TA repeats |
| it-IT | Italian (Italy) | UGT1A1, gene.TA, ripetizioni |
| es-ES | Spanish (Spain) | Repeticiones TA del gen UGT1A1 |
| pl-PL | Polish (Poland) | UGT1A1 gen.TA powtórzenia Synonyms: Powtórzenia TA w genie UGT1A1 |
| el-GR | Greek (Greece) | Γονίδιο UGT1A1.επαναλήψεις ΤΑ Synonyms: Γονίδιο UGT1A1.επαναλήψεις ΤΑ |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://