LP420089-7
Cells.CD3-CD14-CD45+CD56+DOCK8+
Active
Description
Dedicator of cytokinesis 8 (DOCK8) protein plays a role in regulating the cellular cytoskeleton, particularly microfilaments. DOCK8 is important in immunity by contributing to cellular migration, cytotoxicity, antibody production, and immunological memory. Deficiency of DOCK8 causes an immunodeficiency that presents in childhood with features including recurrent sinopulmonary infections, cutaneous viral infection, Staphylococcus aureus skin infections, cancer, and atopic disease (due to hyperimmunoglobulin E). NK cells (CD45+CD14-CD3-CD56+), T cells (CD3+CD14-CD45+), B cells (CD3-CD14-CD19+CD45+), and monocytes (CD45+CD14+) are all expected to express the DOCK8 protein. Therefore, assessment of DOCK8 expression on immune cells facilitates the diagnosis of DOCK8 deficiency. PMID: 28625885 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Cells.CD3-CD14-CD45+CD56+DOCK8+
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2020-08-17
- Construct for LOINC Short Name
- NK Cells DOCK8+
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP420089-7
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| nl-NL | Dutch (Netherlands) | cellen.CD3-CD14-CD45+CD56+DOCK8+ |
| it-IT | Italian (Italy) | Cellule.CD3-CD14-CD45+CD56+DOCK8+ |
| es-ES | Spanish (Spain) | Células CD3-CD14-CD45+CD56+DOCK8+ |
| zh-CN | Chinese (China) | 细胞.CD3-CD14-CD45+CD56+DOCK8+ |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright