LP429545-9
Bacterial trimethoprim resistance dfrA1 gene
Active
Description
Dihydrofolate reductase (DHFR) is an enzyme that changes dihydrofolate to tetrahydrofolate, required for the synthesis of purines, thymidylic acid, and certain amino acids. Due to its critical function, DHFR is found in all organisms. In humans it is encoded by the DHFR gene, and can be the target of drugs such as methotrexate used to treat certain neoplasms and inflammatory diseases. In bacteria, the bacterial DHFR enzyme is targeted by synthetic antibiotics such as trimethoprim. The chromosomal version of the bacterial gene (commonly folA) is sometimes overridden by trimethoprim-resistant versions present on mobile elements. Mutations of DHFR resulted in widespread resistance to trimethoprim. The dfrA class of genes are found to be the largest family of mobile trimethoprim antibiotic resistance genes. PMID: 20169085, [Wiki: Dihydrofolate_reductase] Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Trimethoprim resistance dfrA1 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2021-09-10
- Construct for LOINC Short Name
- dfrA1
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Language Variants Get Info
Tag | Language | Translation |
---|---|---|
it-IT | Italian (Italy) | Resistenza batterica al trimetoprim, gene dfrA1 Synonyms: Gene dfrA1 resistenza al trimetoprim |
nl-NL | Dutch (Netherlands) | bacteriële trimethoprimresistentie dfrA1-gen |
es-ES | Spanish (Spain) | Gen dfrA1 de resistencia bacteriana a la trimetoprima |
zh-CN | Chinese (China) | 细菌三甲氧苄二氨嘧啶耐药 dfrA1 基因 Synonyms: 细菌三甲氧苄二氨嘧啶(TMP、 |
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