Version 2.77

Description

Dihydrofolate reductase (DHFR) is an enzyme that changes dihydrofolate to tetrahydrofolate, required for the synthesis of purines, thymidylic acid, and certain amino acids. Due to its critical function, DHFR is found in all organisms. In humans it is encoded by the DHFR gene, and can be the target of drugs such as methotrexate used to treat certain neoplasms and inflammatory diseases. In bacteria, the bacterial DHFR enzyme is targeted by synthetic antibiotics such as trimethoprim. The chromosomal version of the bacterial gene (commonly folA) is sometimes overridden by trimethoprim-resistant versions present on mobile elements. Mutations of DHFR resulted in widespread resistance to trimethoprim. The dfrA class of genes are found to be the largest family of mobile trimethoprim antibiotic resistance genes. PMID: 20169085, [Wiki: Dihydrofolate_reductase] Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Trimethoprim dfrA12 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2021-09-10
Construct for LOINC Short Name
dfrA12

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP429547-5

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Resistenza batterica al trimetoprim, gene dfrA12
Synonyms: Gene dfrA12 resistenza al trimetoprim
nl-NL Dutch (Netherlands) bacteriële trimethoprimresistentie dfrA12-gen
es-ES Spanish (Spain) Gen dfrA12 de resistencia bacteriana a la trimetoprima
zh-CN Chinese (China) 细菌三甲氧苄二氨嘧啶耐药 dfrA12 基因
Synonyms: 细菌三甲氧苄二氨嘧啶（TMP、三甲氧下二氨嘧啶、甲氧下氨嘧啶、甲氧苄氨嘧啶、磺胺增效剂）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型） dfrA12 基因