LP429664-8

BIRC3 gene

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Description

The BIRC3 gene [HGNC Gene ID: 591] encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] [NCBI Gene ID: 330]
BIRC3 is thought to be important in the pathophysiology of chronic lymphocytic leukemia (CLL), based on the observation of loss of function mutations via its role in modulating NF-kb signaling. PMID: 30487125. Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name

BIRC3 gene

Part Display Name

BIRC3 gene

Part Type

Component (Describes the core component or analyte measured)

Created On

2021-09-17

Construct for LOINC Short Name

BIRC3 gene

Related Codes

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