LP429702-6
PLCG2 gene
Active
Descriptions
Patients with chronic lymphocytic leukemia (CLL) with disease progression treated with ibrutinib has been attributed to histologic transformation or acquired mutations in BTK and PLCG2 genes. PMID: 28049639 Source: PubMed Central
The PLCG2 (phospholipase C gamma 2) gene [HGNC Gene ID: 9066] is located on chromosome 16 at position q23.3. The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014][NCBI Gene ID: 5336] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- PLCG2 gene
- Part Display Name
- PLCG2 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2021-09-22
- Construct for LOINC Short Name
- PLCG2 gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| it-IT | Italian (Italy) | PLCG2, gene Synonyms: Gene PLCG2 |
| nl-NL | Dutch (Netherlands) | PLCG2-gen |
| es-ES | Spanish (Spain) | Gen PLCG2 |
| zh-CN | Chinese (China) | PLCG2 基因 |
| fr-FR | French (France) | PLCG2 gène |
| pl-PL | Polish (Poland) | PLCG2 gen Synonyms: Gen PLCG2 |
| el-GR | Greek (Greece) | Γονίδιο PLCG2 Synonyms: Γονίδιο PLCG2 |
LOINC Copyright
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